Episode 48: Decoding Aging: Science, Healthspan, and the Future of Longevity with Dr. Matt Kaeberlein

A conversation with Dr. Matt Kaeberlein unveils the latest insights into aging, focusing on how studying dogs can illuminate human longevity. The discussion emphasizes the significant role of environmental factors in aging and the potential of interventions like rapamycin. Dr. Matt Kaeberlein, is a world-renowned scientist and leader in the field of aging biology. He is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with additional roles in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s groundbreaking work is dedicated to unraveling the biological mechanisms of aging, paving the way for innovations that enhance healthspan and quality of life—not just for humans but also for our four-legged companions. Dr. Kaeberlein is the founding director of the University of Washington’s Healthy Aging and Longevity Research Institute and the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging. Additionally, he leads the Biological Mechanisms of Healthy Aging Training Program and co-founded the Dog Aging Project, which explores how we can use scientific insights to improve the health and longevity of dogs and, by extension, humans. Throughout his career, Dr. Kaeberlein has delved into cutting-edge research on interventions like rapamycin, NAD+ precursors, metformin, spermidine, and many others, driving conversations at the forefront of aging science. Today we speak about: • Understanding the role of companion animals in aging research • The Dog Aging Project's approach to studying environmental influences • The impact of chronic inflammation on healthspan • Importance of lifestyle changes for longevity • Challenges in funding for aging research • Future possibilities with AI and epigenetic studies in the field • Dr. Kaeberlein’s personal experience with rapamycin and its implications for aging If you have enjoyed listening to and learning from this podcast, please leave a comment, and also you can leave a suggestion for a future podcast guest that you would like us to feature. If you are on Apple, you can leave us a comment, a five-star review, if you can pretty. Please remember, if you want my direct help, send me an email, ed at edpadget.com, or visit my website, edpadgett.com, where you can learn a little bit more about how I can help you make your lifestyle your medicine. Follow Dr. Kaeberlein X: https://x.com/mkaeberlein Website: https://kaeberleinlab.org/  https://www.optispan.life/company

Episode 47: Understanding Mold Toxicity: Expert Insights and Healing Strategies with Dr. Terry Fox

Unlock the secrets to identifying and managing mold toxicity with insights from Dr. Terry Fox, a leading holistic integrative functional medicine expert. This episode promises to shed light on the often-misdiagnosed symptoms of mold exposure, such as fatigue and neurological issues, and how they intertwine with conditions like Lyme disease. Dr. Fox shares her personal journey, revealing how her son's mysterious health struggles led her to unravel the complexities of mold-related illnesses, offering a roadmap for those facing similar unexplained health challenges. Explore advanced strategies for addressing mold and fungal colonization in the body, including the lungs and sinuses. Dr. Fox walks us through effective diagnostic approaches, like urinary and DNA dust tests, and explains a comprehensive two-phase detox protocol. For those dealing with severe cases, discover the role of ENT specialists in surgical interventions and learn about the necessary steps to combat concurrent illnesses like Lyme disease. This episode is packed with actionable advice, making it a must-listen for anyone grappling with mold-related health issues. Gain valuable insights into the mental health implications of mold exposure, particularly its impact on anxiety, depression, and cognitive impairments in children. Dr. Fox discusses how environmental factors, such as toxins, exacerbate these issues and offers practical solutions for reducing mold exposure within the home. Learn about the link between mold and conditions like POTS and mast cell activation syndrome, and get tips on dietary adjustments and home remediation techniques. For more resources and educational content, visit Dr. Fox's website at drfoxmedicaldetective.com and boulderholistic.com, where she continues to guide and support those on the path to recovery.

Episode 46: Unraveling the Mysteries of Omega-3s with Dr. Bill Harris: From Health Benefits to Future Innovations

Join us as Dr. Bill Harris, a distinguished researcher with over 40 years of expertise in the omega-3 field, unravels the mysteries of fatty acids and their vital role in our health. Together, we shed light on the complex landscape of fats, including triglycerides, saturated, and unsaturated fats, and particularly focus on the essential nature of omega-3 and omega-6 polyunsaturated fats. Dr. Harris shares his personal journey into this fascinating field, offering insights into the molecular structure and distinctive characteristics of omega-3 fatty acids. Discover the profound health benefits that omega-3s, especially those derived from fish oils, can provide in promoting long-term well-being. We tackle misconceptions about supplements, such as blood thinning fears, and emphasize the non-threatening nature of typical doses. Learn how a diet rich in omega-3s is linked to a reduced risk of heart disease, diabetes, and certain cancers, highlighting their significance as essential nutrients. We also address the challenges in distinguishing the benefits of omega-3s from other healthy lifestyle factors, underscoring the need for comprehensive research to fully understand their impact. Explore the potential of omega-3s across different life stages, from pregnancy to old age, and their role in mitigating risks of autoimmune diseases and cognitive decline. Dr. Harris introduces the Omega-3 Index, a groundbreaking tool for assessing heart disease risk, and shares practical advice on supplementation, including the importance of testing. As we look to the future, the conversation shifts to innovative sources of omega-3s, such as genetically modified seed oils, which promise a sustainable alternative to traditional fish-based options. This episode is a treasure trove of information for anyone eager to enhance their health using the power of omega-3 fatty acids.

Episode 45: Jacopo Iasiello – A Journey of Meditation and Wealth

Imagine transforming a life-altering setback into a launching pad for success—that’s precisely what our guest, Jacobo Izielo, did. We uncover the remarkable story of a young soccer prodigy from Italy who, after a career-ending injury, made the journey from the pitch to prosperity with a burgeoning jewelry empire by age 22. Izielo offers insights into how his resilience and fascination with the lives of figures like Gandhi and Mother Teresa ignited his passion for entrepreneurship, redefining his life’s path in the face of adversity. Transitioning from his thriving jewelry business to the dynamic real estate market in the U.S., Jacobo faced significant challenges, including language barriers and cultural shifts. Yet, this did not deter him. Relocating to Florida in the aftermath of the 2009 crash, he strategically built a real estate portfolio, flipping over 355 properties and creating substantial cash flow. Listen as he shares the lessons learned from strategic networking and seizing opportune moments, transforming challenges into stepping stones for success. Jacobo also delves into the holistic approach to balancing wealth with personal well-being. Through practices like transcendental meditation and biohacking, he emphasizes the MPBB method—meditation, prayer, biohacking, and exercise—as key components of self-improvement. He offers a glimpse into how these practices, alongside smart real estate investment strategies, contribute to a fulfilling life. As we conclude, Jacobo highlights his commitment to spreading positivity and knowledge through his book and online platforms, aiming to inspire others to align their financial and personal health goals for a truly enriched life.